Selected Publications
Harris CT, Tong X, Campelo R, Marreiros IM, Vanheer LN, Nahiyann N, Zuarte-Luis VA, Deitsch KW, Mota MM, Rhee KY, Kafsack BFC.
Metabolic competition between lipid metabolism and histone methylation regulates sexual differentiation in human malaria parasites.
Nature Microbiology. 2023 (in press).
Schneider VM, Visone JE, Harris CT, Florini F, Hadjimichael E, Zhang X, Gross MR, Rhee KY, Mamoun CB, Kafsack BFC, Deitsch KW.
The human malaria parasite Plasmodium falciparum can sense environmental changes and respond by antigenic switching.
PNAS. 2023 (in press)
Campelo Morillo R, Harris CT, Kennedy K, Henning SR, Kafsack BFC.
Global Profiling of Histone Modifications in Plasmodium falciparum using CUT&RUN.
Life Science Alliance 2022 Nov. 15
Malave-Ramos DR, Kennedy K, Key MN, Dou Z, Kafsack BFC.
Safe, effective, and inexpensive clearance of mycoplasma contamination from cultures of apicomplexan parasites with Sparfloxacin.
Microbiology Spectrum 2022 Oct 3.
Nötzel C, Kafsack BFC.
PfD123 modulates K13-mediated survival and recovery after artemisinin exposure.
BioRXiv. 2022 Jan 28.
Campelo R, Tong X, Xie W, Able S, Orchard LM, Daher W, Patel DJ, Llinás M, Le Roch KG, Kafsack BFC.
The essential transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.
Nature Microbiology, volume 7, pages289–299 (2022)
Nötzel C, Kafsack BFC.
There and back again: malaria parasite single-cell transcriptomics comes full circle.
Trends in Parasitology 2021 Aug 11; S1471-4922(21)00176-8
Vanheer N, Kafsack BFC.
Activity Comparison of Epigenetic Modulators against the Hemoprotozoan Parasites Babesia divergens and Plasmodium falciparum
ACS Infectious Diseases 2021 Aug 13; 13;7(8):2277-2284
Reed J, Kirkman LA, Kafsack BFC, Mason C, Deitsch KW.
Telomere length dynamics in response to DNA damage in malaria parasites.
iScience, 2021 Feb 18, (24) 102082
Neveu G, Beri D, Kafsack BFC.
Metabolic regulation of sexual commitment in malaria parasites.
Current Opinion in Microbiology. 2020 Dec, 58:93-98
Vanheer LN, Zhao H, Gan, L, Kafsack BFC.
Activity of epigenetic inhibitors against Plasmodium falciparum asexual and sexual blood stages.
Antimicrobial Agents & Chemotherapy 2020 Jun 23;64(7):e02523-19, PMID: 32366713
McLean KJ, Straimer J, Hopp CS, Vega-Rodriguez J, Tripathi A, Mlambo G, Doumolin PC, Harris CT, Tong X, Shears MJ, Ankarklev J, Kafsack BFC, Fidock DA, Sinnis P.
Generation of Transgenic Human Malaria Parasites with Strong Fluorescence in the Transmission Stages.
Scientific Reports. 2019 Sep 11;9(1):13131. PMID: 31511546
Matthews K, Senagbe K, Nötzel C, Gonzalez C, Tong X, Rijo-Ferreira F, Natarajan B, Miguel-Blanco C, Lafuente-Monasterio M, Garcia B, Kafsack B, Martinez E. Disruption of the Plasmodium falciparum life cycle through transcriptional reprogramming by inhibitors of Jumonji demethylases.
ACS Infectious Diseases. 2020 Apr 9. PMID: 32272012
Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick GD, Wong TT, Okoro JI, Scales RM, Tumwebaze PT, Rosenthal PJ, Kafsack BFC, Cooper R, Meinke PT, Kirkman LA, Lin G.
Improvement of asparagine ethylenediamines as anti-malarial Plasmodium-selective proteasome inhibitors.
Journal of Medical Chemistry 2019 Jun 9. PMID: 31177777
Bancells C, Llorà-Batlle O, Poran P, Nötzel N, Rovira-Graells N, Elemento O, Kafsack BFC, Cortés A.
Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum.
Nature Microbiology. 2019 Jan;4(1):144-154.PMID: 30478286
Nötzel C*, Poran A*, Kafsack BFC
Single-Cell Transcriptome Profiling of Protozoan and Metazoan Parasites.
Trends in Parasitology 2017, Published online May 25, 2018 *authors contributed equally
Kirkman L, Zhan W, Visone V, Dziedziech A, Fan H, Singh PK, Tong X, Bruzual I, Hara R, Kawasaki M, Sato K, Michino M, Aso K, Fernandez Alvaro E, Wang R, Ling Y, Guiang LF, Sanz L, Mota D, Kavitha G, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Cooper R, Kafsack BFC, Doggett JS, Nathan C, Lin G. Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.
PNAS 2018 Jul 17;115(29)
Poran A*, Nötzel C*, Aly O, Mencia-Trinchant N, Harris CT, Guzman ML, Hassane DC, Elemento O, Kafsack BFC
Single-cell RNA sequencing reveals a signature of sexual commitment in malaria parasites.
Nature 2017 Nov 2;551(7678):95-99. *authors contributed equally
Coleman B, Skillman K, Jiang R, Childs L, Altenhofen L, Ganter M, Leung Y, Goldowitz I, Kafsack B, Marti M, Llinas M, Buckee C, Duraisingh M.
A Plasmodium falciparum Histone Deacetylase Regulates Antigenic Variation and Gametocyte Conversion.
Cell Host & Microbe 2014 Aug 13; 16(2):177-86.
Kafsack BFC, Rovira-Graells N, Clark TG, Christina Bancells, Crowley VM, Campino SG, Williams AE, Drought LG, Kwiatkowski DP, Baker DA, Cortés A, Llinás M.
A transcriptional switch controls commitment to sexual development in malaria parasites.
Nature 2014 507(7491):248-52.
Sinha A, Hughes KR, Modrzynska KK, Otto TD, Pfander C, Dickens NK, Religa AA, Bushell E, Graham AL, Cameron R, Kafsack, BFC, Williams A, Llinás M, Berriman M, Billker O, Waters AP.
A cascade of DNA binding proteins for sexual commitment and development in Plasmodium.
Nature 2014 507(7491) pp. 253-7.
Carter LM, Kafsack BFC, Llinás M, Mideo N, Pollitt LC, Reece SE.
Stress and Sex in Malaria Parasites: Why Does Commitment Vary?
Evolution, Medicine, and Public Health. 2013 (1):135-147
Painter HJ, Altenhofen LM, Kafsack BF, Llinás M.
Whole-Genome Analysis of Plasmodium spp. Utilizing a New Agilent Technologies DNA Microarray Platform.
Methods Mol Biol. 2013; 923:213-9.
Kafsack BFC*, Painter HJ*, Llinás M.
New Agilent platform DNA microarrays for transcriptome analysis of P. falciparum and P. berghei for the malaria research community.
Malaria J. 2012 11:187 *authors contributed equally
Kafsack BFC, Llinás M.
Eating at the Table of Another: Metabolomics of Host/Parasite Interactions.
Cell: Host & Microbe 2010 Feb 7(2):90-99
Kafsack BFC, Carruthers VB.
Apicomplexan MACPF Proteins,
Commun Integr Biol. 2010 Jan/Feb: 3(1):68-73
Lagal V, Binder EM, Huynh MH, Kafsack BFC, Harris PK, Diez R, Chen D, Cole RN, Carruthers VB, Kim K.
Toxoplasma gondii Protease TgSUB1 is Required for Cell Surface Processing of Micronemal Adhesive Complexes and Efficient Attachment of Tachyzoites to Host Cells.
Cellular Microbio. 2010 (12):1792-1808
Kafsack BFC, Pena J, Coppens I, Ravindran S, Boothroyd JC, Carruthers VB.
Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cell.
Science 2009 Vol. 323, No. 5913, pp. 530-533.
Kafsack BFC, Carruthers VB, Pineda FJ.
Kinetic Modeling of Toxoplasma Invasion.
J Theo. Biol. 2007 Dec, 249(4):817-25
Zhou XW*, Kafsack BFC*, Cole RN, Beckett P, Shen RF, Carruthers VB.
The Opportunistic Pathogen Toxoplasma Gondii Deploys A Diverse Legion Of Invasion And Survival Proteins.
J. Biol. Chem. 2005 Oct 7;280(40):34233-44 *authors contributed equally
Kafsack BFC, Beckers CJM, Carruthers VB.
Synchronous invasion of host cells by Toxoplasma gondii.
Mol. Biochem. Parasitol. 2004 Aug; 136(2):309-311
Harper JM, Zhou XW, Pszenny V, Kafsack BFC, Carruthers VB.
The novel coccidian micronemal protein MIC11 undergoes proteolytic maturation by sequential cleavage to remove an internal propeptide.
Int J Parasitol 2004 Aug; 34(9):1047-58
Rasoloson D, Shi L, Chong CR, Kafsack BF, Sullivan DJ.
Copper pathways in Plasmodium falciparum infected erythrocytes indicate an efflux role for the copper P-ATPase.
Biochem J. 2004 Aug 1;381(Pt 3):803-11